Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung.

@article{Yi2009FibroblastGF,
  title={Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung.},
  author={Lan Yi and Eric Thomas Domyan and Mark B Lewandoski and Xin Sun},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 1},
  pages={123-37}
}
In mammalian lungs, airway smooth muscle cells (airway SMCs) are present in the proximal lung adjacent to bronchi and bronchioles, but are absent in the distal lung adjacent to terminal sacs that expand during gas exchange. Evidence suggests that this distribution is essential for the formation of a functional respiratory tree, but the underlying genetic mechanism has not been elucidated. In this study, we test the hypothesis that fibroblast growth factor 9 (Fgf9) signaling is essential to… CONTINUE READING

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