Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding.

Abstract

Exercise is an effective therapy against the metabolic syndrome. However, the molecular pathways underlying the advantageous effects of exercise are elusive. Glucagon receptor signaling is essential for exercise benefits, and recent evidence indicates that a downstream effector of glucagon, fibroblast growth factor 21 (FGF21), is implicated in this response… (More)
DOI: 10.1152/japplphysiol.00456.2016

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Cite this paper

@article{Loyd2016FibroblastGF, title={Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding.}, author={Christine M. Loyd and Irwin J Magrisso and Michael Haas and Sowmya Balusu and Radha Krishna and Nobuyuki Itoh and Darleen A. Sandoval and Diego P{\'e}rez-Tilve and Silvana Obici and Kirk M Habegger}, journal={Journal of applied physiology}, year={2016}, volume={121 3}, pages={687-98} }