Fibroblast growth factor 21 enhances angiogenesis and wound healing of human brain microvascular endothelial cells by activating PPARγ.

@article{Huang2019FibroblastGF,
  title={Fibroblast growth factor 21 enhances angiogenesis and wound healing of human brain microvascular endothelial cells by activating PPARγ.},
  author={Wenting Huang and Mingjie Shao and Huan Liu and Jun Chen and Jiang-Ning Hu and Liyun Zhu and Fei Liu and Dongxue Wang and Yuchi Zou and Y Xiong and Xue Wang},
  journal={Journal of pharmacological sciences},
  year={2019}
}
Angiogenesis of brain microvascular endothelial cells (BMECs) is required in the functional restoration of brain injury, such as traumatic brain injury (TBI) and ischemic stroke. Fibroblast growth factor 21 (FGF21) is an angiogenic molecule that functions through the formation of the FGF21/FGFR1/β-klotho complex but does not cause carcinogenic events. The current study was to determine whether recombinant human FGF21 (rhFGF21) could promote angiogenesis and scratch wound healing of human brain… CONTINUE READING
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