Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.

  title={Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.},
  author={Yu Cho Woo and Aimin Xu and Yu Wang and Karen S. L. Lam},
  journal={Clinical endocrinology},
  volume={78 4},
Fibroblast growth factor 21 (FGF21), a metabolic hormone predominantly produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose and lipid metabolism through pleiotropic actions in these tissues and the brain. In mice, fasting leads to increased PPAR-α mediated expression of FGF21 in the liver where it stimulates gluconeogenesis, fatty acid oxidation, and ketogenesis, as an adaptive response to fasting and starvation. In the fed state, FGF21 acts as an… CONTINUE READING


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