Fibroblast growth factor-2 over-rides insulin-like growth factor-I induced proliferation and cell survival in human neuroblastoma cells.

@article{Russo2004FibroblastGF,
  title={Fibroblast growth factor-2 over-rides insulin-like growth factor-I induced proliferation and cell survival in human neuroblastoma cells.},
  author={Vincenzo C. Russo and E Andaloro and S A Fornaro and Suzana Najdovska and Donald F. Newgreen and Leon A Bach and George Arthur Werther},
  journal={Journal of cellular physiology},
  year={2004},
  volume={199 3},
  pages={
          371-80
        }
}
The insulin-like growth factor (IGF) system is a key regulator of cell growth, survival and differentiation, and these functions are co-modulated by other growth factors including fibroblast growth factor-2 (FGF-2). To investigate IGF/FGF interactions in neuronal cells, we employed neuroblastoma cells (SK-N-MC). In serum free conditions proliferation of the SK-N-MC cells was promoted by IGF-I (25 ng/ml), but blunted by FGF-2 (50 ng/ml). IGF-I-induced proliferation was abolished in the presence… CONTINUE READING

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