Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy.

@article{Tsai2007FibroblastGF,
  title={Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy.},
  author={Tsung-Ting Tsai and Asha Guttapalli and Erbil Oguz and Li-Huei Chen and Alexander R. Vaccaro and Todd J. Albert and Irving M. Shapiro and Makarand V. Risbud},
  journal={Spine},
  year={2007},
  volume={32 5},
  pages={495-502}
}
STUDY DESIGN To investigate effects of FGF-2 on nucleus pulposus cell growth and differentiation. OBJECTIVES To elucidate the phenotypic changes that occur during expansion of nucleus pulposus cells in monolayer culture, and to investigate the effects of fibroblast growth factor (FGF)-2 on cell growth and differentiation. SUMMARY OF BACKGROUND DATA Nucleus pulposus cells would have a limited application for autologous cell transplantation if phenotypic dedifferentiation takes place during… CONTINUE READING
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