Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.

@article{Guzy2015FibroblastGF,
  title={Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.},
  author={Robert D Guzy and Ivan Stoilov and Timothy J Elton and Robert P. Mecham and David M Ornitz},
  journal={American journal of respiratory cell and molecular biology},
  year={2015},
  volume={52 1},
  pages={116-28}
}
The pathogenesis of pulmonary fibrosis involves lung epithelial injury and aberrant proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung function. In vitro, fibroblast growth factor (FGF) 2 promotes myofibroblast differentiation and proliferation in cooperation with the profibrotic growth factor, transforming growth factor-β1, but the in vivo requirement for FGF2 in the development of pulmonary fibrosis is not known. The bleomycin model of lung injury… CONTINUE READING
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