Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

@article{Chia2009FibroblastGF,
  title={Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.},
  author={Shi-lu Chia and Yasunobu Sawaji and Annika Burleigh and Celia McLean and Julia J. Inglis and Jeremy Saklatvala and Tonia L. Vincent},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 7},
  pages={
          2019-27
        }
}
OBJECTIVE We have previously identified in articular cartilage an abundant pool of the heparin-binding growth factor, fibroblast growth factor 2 (FGF-2), which is bound to the pericellular matrix heparan sulfate proteoglycan, perlecan. This pool of FGF-2 activates chondrocytes upon tissue loading and is released following mechanical injury. In vitro, FGF-2 suppresses interleukin-1-driven aggrecanase activity in human cartilage explants, suggesting a chondroprotective role in vivo. We undertook… CONTINUE READING
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