Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells.

@article{Nakahara2010FibroblastGF,
  title={Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells.},
  author={Takehiro Nakahara and Hiroko Sato and Takehisa Shimizu and Toru Tanaka and Hiroki Matsui and Keiko Kawai-Kowase and Mahito Sato and Tatsuya Iso and Masashi Arai and Masahiko Kurabayashi},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 2},
  pages={243-8}
}
Expression of bone-associated proteins and osteoblastic transcription factor Runx2 in arterial cells has been implicated in the development of vascular calcification. However, the signaling upstream of the Runx2-mediated activation of osteoblastic program in vascular smooth muscle cells (VSMC) is poorly understood. We examined the effects of fibroblast growth factor-2 (FGF-2), an important regulator of bone formation, on osteoblastic differentiation of VSMC. Stimulation of cultured rat aortic… CONTINUE READING

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