Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo

@article{Butt2005FibroblastGF,
  title={Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo},
  author={Arthur M Butt and Jennifer Dinsdale},
  journal={Experimental Neurology},
  year={2005},
  volume={192},
  pages={125-133}
}
Oligodendrocytes are the myelin-forming cells of the CNS and are lost in demyelinating diseases such as multiple sclerosis (MS). A role for fibroblast growth factor 2 (FGF2) has been proposed in the pathogenesis of demyelination and the failure of remyelination in experimental models of MS. However, the in vivo effects of FGF2 on oligodendrocytes and oligodendrocyte progenitors (OPCs) in the adult CNS had not previously been determined. To address this, FGF2 was delivered into the cerebrospinal… CONTINUE READING

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