Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice.

@article{Cooke2006FibroblastGF,
  title={Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice.},
  author={Vesselina G. Cooke and Meghna U. Naik and Ulhas P. Naik},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 9},
  pages={2005-11}
}
OBJECTIVE We have previously shown that JAM-A regulates fibroblast growth factor-2 (FGF-2)-induced endothelial cell morphology, proliferation, and migration. Whether JAM-A is involved in FGF-2-induced angiogenesis in vivo is not known. We used JAM-A null mice to conclusively determine the role of JAM-A in FGF-2-induced neovascularization. METHODS AND RESULTS We generated JAM-A null (JAM-A(-/-)) mice using gene trap technology. These mice, although viable and fertile, exhibited distorted… CONTINUE READING

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References

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JAM-A expression during embryonic development.

Developmental dynamics : an official publication of the American Association of Anatomists • 2005

Manipulating angiogenesis in medicine.

Journal of internal medicine • 2004

Junctional adhesion molecule 1 (JAM-1).

Journal of biological regulators and homeostatic agents • 2003

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