Fibroblast growth factor-2 binding to the endothelial basement membrane peaks at a physiologically relevant shear stress.

@article{Reisig2010FibroblastGF,
  title={Fibroblast growth factor-2 binding to the endothelial basement membrane peaks at a physiologically relevant shear stress.},
  author={Karl V. Reisig and Alisa Morss Clyne},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2010},
  volume={29 7},
  pages={586-93}
}
Fibroblast growth factor-2 (FGF2) is produced and released by endothelial cells and binds to heparan sulfate proteoglycans in the endothelial basement membrane (BM), an important FGF2 storage reservoir. Experimental and computational models of FGF2 binding kinetics to both cells and BM under static conditions are well established in the literature but remain largely unexplored under flow. We now examine BM-FGF2 binding kinetics in fluid flow conditions. We hypothesized that FGF2 binding to the… CONTINUE READING
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