Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.

@article{BocelliTyndall2010FibroblastGF,
  title={Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.},
  author={Chiara Bocelli-Tyndall and Paul Zajac and Nunzia Di Di Maggio and Emanuele Trella and Federica Benvenuto and Giandomenica Iezzi and Arnaud Scherberich and A. Pablo L. Barbero and Stefan Schaeren and Vito Pistoia and Giulio Spagnoli and Mirko Vukcevic and Ivan Martin and Alan Tyndall},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 12},
  pages={
          3815-25
        }
}
OBJECTIVE To document the specificity and the mechanism of induction of a novel class II major histocompatibility complex (MHC) antigen by mitogenic growth factors in human mesenchymal stem cells (MSCs) expanded in vitro for translational applications. METHODS Expression of class II MHC molecules was measured in human MSCs and differentiated cells expanded in the presence of fibroblast growth factor 2 (FGF-2), platelet-derived growth factor BB (PDGF-BB), human platelet lysate, or interferon… CONTINUE READING