Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

@article{Inagaki2005FibroblastGF,
  title={Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.},
  author={Takeshi Inagaki and Mihwa Choi and Antonio Moschetta and Li Peng and Carolyn L Cummins and Jeffrey G McDonald and Guizhen Luo and Stacey A. Jones and Bryan Goodwin and J. A. Richardson and Robert D. Gerard and Joyce J. Repa and David J Mangelsdorf and Steven A. Kliewer},
  journal={Cell metabolism},
  year={2005},
  volume={2 4},
  pages={217-25}
}
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the first and rate-limiting step in the classical bile acid synthetic pathway. FGF15 expression is stimulated in the small intestine by the nuclear bile acid receptor FXR and represses Cyp7a1 in liver through a mechanism that involves FGF… CONTINUE READING
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