Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways

@article{Yu2015FibroblastGF,
  title={Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways},
  author={Yinhang Yu and Fuliang Bai and Yaonan Liu and Yongbi Yang and Qingyan Yuan and Dehua Zou and Susu Qu and Guiyou Tian and Liying Song and Tong Zhang and Siming Li and Yunye Liu and Wen-fei Wang and Guiping Ren and De-shan Li},
  journal={Molecular and Cellular Biochemistry},
  year={2015},
  volume={403},
  pages={287-299}
}
FGF21 is recently discovered with pleiotropic effects on glucose and lipid metabolism. However, the potential protective effect of FGF21 against d-gal-induced injury in the liver has not been demonstrated. The aim of this study is to investigate the pathophysiological role of FGF21 on hepatic oxidative injury and apoptosis in mice induced by d-gal. The 3-month-old Kunming mice were subcutaneously injected with d-gal (180 mg kg−1 d−1) for 8 weeks and administered simultaneously with FGF21 (5 or… CONTINUE READING

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