Fibroblast growth factor‐19: Development, analytical characterization and clinical evaluation of a new ELISA test

@article{Stejskal2008FibroblastGF,
  title={Fibroblast growth factor‐19: Development, analytical characterization and clinical evaluation of a new ELISA test},
  author={David Stejskal and Michal Karp{\'i}{\vs}ek and Zuzana Hanulova and Pavel Stejskal},
  journal={Scandinavian Journal of Clinical and Laboratory Investigation},
  year={2008},
  volume={68},
  pages={501 - 507}
}
Objective. Since fibroblast growth factor 19 (FGF‐19) is a potent metabolic regulator that influences glucose and lipid homeostasis, our aim was to develop an ELISA assay for measuring FGF‐19 in human serum and to investigate its concentrations in healthy volunteers and patients suffering from metabolic syndrome. Material and methods. A sandwich ELISA method was developed for quantitative determination of human FGF‐19 in serum samples. Blood pressure, waist circumference, FGF‐21 serum levels… 
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References

SHOWING 1-8 OF 8 REFERENCES
Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
TLDR
Evidence is provided that the transintestinal flux of BAs regulates serum levels of intestinal fibroblast growth factor 19 (FGF19) that in turn modulate BA production in human liver, and that FGF19 modulates hepatic BA synthesis.
Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.
TLDR
It is reported that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure and did not become obese or diabetic on a high fat diet.
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.
TLDR
Treatment with FGF19 prevented or reversed the diabetes that develops in mice made obese by genetic ablation of brown adipose tissue or genetic absence of leptin, and profiled the F GF19-induced gene expression changes in the liver and brown fat.
FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
TLDR
FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding toFGFR4.
Actions and mode of actions of FGF19 subfamily members.
TLDR
Investigation indicated that FGF19 subfamily members, FGF15/19, F GF21 and FGF23 work as systemic factors and together with their receptor systems might be targets for novel therapeutic measures in the future.
Biliary secretion and excretion in health and disease: current concepts.
  • A. Hofmann
  • Medicine, Biology
    Annals of hepatology
  • 2007