Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum.

@article{Cool2006FibroblastFA,
  title={Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum.},
  author={Carlyne D Cool and Steve D. Groshong and Pradeep R. Rai and Peter M Henson and J. Scott Stewart and Kevin K. Brown},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 6},
  pages={654-8}
}
BACKGROUND Usual interstitial pneumonia (UIP), the pathologic correlate of idiopathic pulmonary fibrosis, contains characteristic discrete areas of fibroblasts, myofibroblasts, and newly formed collagen, termed "fibroblast foci." These lesions are argued to represent isolated sites of recurrent acute lung injury and suggested to be the mechanism of disease progression. We hypothesized that, rather than isolated, these lesions are part of an organized neoplasm. METHODS Morphometric analysis of… CONTINUE READING

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