Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

@inproceedings{Hessmann2018FibroblastDS,
  title={Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer},
  author={Elisabeth Hessmann and M S Patzak and Laura S Klein and N Chen and Vijayalaxmi Kari and I Ramu and Tashinga E Bapiro and Kristopher K. Frese and Aarthi Gopinathan and Frances M. Richards and Duncan I. Jodrell and Caroline Sophie Verbeke and Xiaoxing Li and Rainer Heuchel and Johannes Matthias L{\"o}hr and Steven A Johnsen and Thomas Matthias Gress and Volker Ellenrieder and Albrecht Neesse},
  booktitle={Gut},
  year={2018}
}
OBJECTIVE Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery. DESIGN Gemcitabine metabolites were analysed in LSL-KrasG12D/+ ; LSL-Trp53R172H/+ ; Pdx-1-Cre (KPC) murine tumours and matched liver metastases, primary tumour cell lines… CONTINUE READING
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