Fibroblast contraction of collagen lattices in vitro: inhibition by chronic inflammatory cell mediators.

@article{Ehrlich1983FibroblastCO,
  title={Fibroblast contraction of collagen lattices in vitro: inhibition by chronic inflammatory cell mediators.},
  author={H. Paul Ehrlich and David J. Wyler},
  journal={Journal of cellular physiology},
  year={1983},
  volume={116 3},
  pages={345-51}
}
Fibroblast-populated collagen lattices (FPCL), prepared in petri dishes with serum-containing culture medium and incubated at 37 degrees C, undergo progressive and symmetric contraction (reduction in size) over a period of days. The in vitro contraction process requires viable cells with intact cytoskeletal elements, is associated with cell elongation, and is believed to represent a fibroblast function which also occurs in vivo during wound healing and tissue fibrosis. We report that soluble… CONTINUE READING