Fibroblast activation protein and focal adhesion kinase: novel stromal therapeutic targets in pancreatic adenocarcinoma.

Abstract

4094 Background: Fibroblast activation protein (FAP) is a serine protease expressed on tumor stromal fibroblasts which results in tumor growth potentiation. Focal adhesion kinase (FAK) is a protein tyrosine kinase which promotes cell growth and migration through the extracellular matrix. Given the extensive desmoplasia characteristic of pancreatic… (More)

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