Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions

@article{Huang2011FibroblastAP,
  title={Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions},
  author={Yan Huang and Avis E. Simms and Anna Mazur and Sophie Yu Wang and Noel R. Le{\'o}n and Barry Jones and Nazneen Aziz and Thomas G Kelly},
  journal={Clinical & Experimental Metastasis},
  year={2011},
  volume={28},
  pages={567-579}
}
Fibroblast activation protein-α (FAP) is a cell surface, serine protease of the post-prolyl peptidase family that is expressed in human breast cancer but not in normal tissues. Previously, we showed that FAP expression increased tumor growth rates in a mouse model of human breast cancer. Here the role of the proteolytic activities of FAP in promoting tumor growth, matrix degradation and invasion was investigated. Mammary fat pads of female SCID mice were inoculated with breast cancer cells that… CONTINUE READING
30 Citations
57 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…