Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions.

@article{Yamakawa2015FibroblastGF,
  title={Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions.},
  author={Hiroyuki Yamakawa and Naoto Muraoka and Kazutaka Miyamoto and Taketaro Sadahiro and Mari Isomi and Sho Haginiwa and Hidenori Kojima and Tomohiko C Umei and Mizuha Akiyama and Yuki Kuishi and Junko Kurokawa and Tetsushi Furukawa and Keiichi Fukuda and Masaki Ieda},
  journal={Stem cell reports},
  year={2015},
  volume={5 6},
  pages={
          1128-1142
        }
}
Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by overexpression of cardiac transcription factors, including Gata4, Mef2c, and Tbx5; however, this process is inefficient under serum-based culture conditions, in which conversion of partially reprogrammed cells into fully reprogrammed functional iCMs has been a major hurdle. Here, we report that a combination of fibroblast growth factor (FGF) 2, FGF10, and vascular endothelial growth factor (VEGF), termed FFV… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 35 CITATIONS

In Vivo Reprogramming in Regenerative Medicine

  • Stem Cell Biology and Regenerative Medicine
  • 2017
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Effect of biophysical cues on reprogramming to cardiomyocytes.

VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

In Vivo Cellular Reprogramming: The Next Generation

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Medical Applications of iPS Cells

  • Current Human Cell Research and Applications
  • 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Hepatocyte growth factor (HGF) enhances cardiac commitment of differentiating embryonic stem cells by activating PI3 kinase

C. Roggia, C. Ukena, M. Böhm, H. Kilter
  • Exp. Cell Res
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers