Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

@inproceedings{Sarruf2010FibroblastGF,
  title={Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats},
  author={David A. Sarruf and Joshua P. Thaler and Gregory J. Morton and Jonathan P. German and Jonathan D. Fischer and Kayoko Ogimoto and Michael J. Schwartz},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE The hormone fibroblast growth factor 21 (FGF21) exerts diverse, beneficial effects on energy balance and insulin sensitivity when administered systemically to rodents with diet-induced obesity (DIO). The current studies investigate whether central FGF21 treatment recapitulates these effects. RESEARCH DESIGN AND METHODS After preliminary dose-finding studies, either saline vehicle or recombinant human FGF21 (0.4 microg/day) was infused continuously for 2 weeks into the lateral… CONTINUE READING
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SARRUF AND ASSOCIATES diabetes.diabetesjournals.org DIABETES

  • AC Könner, R Janoschek, +5 authors D. A. Enriori
  • Cell Metab
  • 2010

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