Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid

  title={Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid},
  author={Bee Kang Tan and Manfred Hallschmid and Raghu Adya and Werner Kern and Hendrik Lehnert and Harpal Randeva},
OBJECTIVE Reports of increased circulating fibroblast growth factor 21 (FGF21) levels in obesity indicate that FGF21 may be implicated in body weight homeostasis. We sought to investigate the existence of FGF21 in human cerebrospinal fluid (CSF) and, if present, the relationship between CSF FGF21 with body adiposity and metabolic parameters. RESEARCH DESIGN AND METHODS CSF and corresponding plasma FGF21 were measured by an enzyme-linked immunosorbent assay (18 men and 20 women, aged 19-80… CONTINUE READING

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