Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.

@article{Dunshee2016FibroblastAP,
  title={Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.},
  author={Diana Ronai Dunshee and Travis W. Bainbridge and Noelyn M. Kljavin and Jose Zavala-Solorio and Amy C. Schroeder and Ruby Chan and Racquel T. Corpuz and Manda Wong and Wei Zhou and Gauri P. Deshmukh and Justin Ly and Daniel P. Sutherlin and James A. Ernst and Junichiro Sonoda},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 11},
  pages={5986-96}
}
FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood. Here we identify fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21. A selective chemical inhibitor, immunodepletion, or genetic deletion of Fap stabilized… CONTINUE READING