Fibroblast (heparin-binding) growing factors in neuronal development and repair

  title={Fibroblast (heparin-binding) growing factors in neuronal development and repair},
  author={Laurence W. Haynes},
  journal={Molecular Neurobiology},
Nearly thirty growth and trophic factors that have been purified from mammalian tissues in the last 15 yr have been found to share chemical identity. The results of their chemical purification and molecular cloning show that they are two distinct polypeptides (Mr 17,400 and 18,400), each of which gives rise to families of smaller size peptides. These peptides share a common affinity for heparin. In view of this property, a common nomenclature for the two principle peptide growth factors… CONTINUE READING
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A recent report further supports the existence of high molecular weight forms (27-29,000 Da) of bFGF in brain tissue of the rat

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