Fibrinolysis in disseminated intravascular coagulation.

  title={Fibrinolysis in disseminated intravascular coagulation.},
  author={C. Erik Hack},
  journal={Seminars in thrombosis and hemostasis},
  volume={27 6},
  • C. Erik Hack
  • Published 2001 in Seminars in thrombosis and hemostasis
Studies in experimental models for sepsis, the most common cause of disseminated intravascular coagulation (DIC), have put forward the concept of a procoagulant state that is characterized by thrombin generation exceeding that of plasmin. Convincing evidence indicates that this imbalance between coagulation and fibrinolysis is due to increased levels of plasminogen activator inhibitor type 1 (PAI-1). Levels of this fibrinolysis inhibitor indeed correlate with outcome and severity of multiple… CONTINUE READING