Fibrinolysis in a lipid environment: modulation through release of free fatty acids

@article{Rbai2007FibrinolysisIA,
  title={Fibrinolysis in a lipid environment: modulation through release of free fatty acids},
  author={Gy{\"o}ngyi R{\'a}bai and Balazs Varadi and Colin Longstaff and P{\'e}ter Tam{\'a}s S{\'o}tonyi and Vera Krist{\'o}f and Ferenc T{\'i}m{\'a}r and Raymund Machovich and Krasimir Kolev},
  journal={Journal of Thrombosis and Haemostasis },
  year={2007},
  volume={5},
  pages={1265 - 1273}
}
BACKGROUND Thrombolysis is conventionally regarded as dissolution of the fibrin matrix of thrombi by plasmin, but the structure of clots in vivo includes additional constituents (proteins, phospholipids) that modulate their solubilization. OBJECTIVE We examined the presence of free fatty acids in thrombi and their effects on distinct stages of fibrinolysis (plasminogen activation, plasmin activity). METHODS AND RESULTS Using the fluorescent probe acrylodated intestinal fatty acid-binding… CONTINUE READING
BETA

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