Fibrinolysis in LPS-induced chronic airway disease.

@article{Savov2003FibrinolysisIL,
  title={Fibrinolysis in LPS-induced chronic airway disease.},
  author={Jordan D. Savov and David M. Brass and Katherine Gray Berman and Erin McElvania and David A Schwartz},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 4},
  pages={L940-8}
}
To examine the role of the fibrinolytic system in LPS-induced airway disease, we compared the effect of a chronic LPS challenge in plasminogen activator inhibitor-deficient (C57BL/6JPAI-1-/-) mice and wild-type (WT) C57BL/6J mice. Physiological and biological assessments were performed, immediately after, and 4 wk after an 8-wk exposure to LPS or saline. Immediately after the LPS exposure, WT mice had increased estimates of airway reactivity to methacholine compared with C57BL/6JPAI-1-/- mice… CONTINUE READING

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Control of type IV collagenase activity by components of the urokinase-plasmin system: a reg L947 LPS-INDUCED AIRWAY DISEASE IN PAI-1-DEFICIENT MICE

  • R Mazzieri, L Masiero, +4 authors P. Mignatti
  • AJP-Lung Cell Mol Physiol
  • 2003
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