Fibrinolysis Autographs

@article{Todd1958FibrinolysisA,
  title={Fibrinolysis Autographs},
  author={A. S. Todd},
  journal={Nature},
  year={1958},
  volume={181},
  pages={495-496}
}
  • A. Todd
  • Published 1958
  • Medicine
  • Nature
Permin and Astrup used a plate method of demonstrating fibrinolytic activity1,2. This technique can be applied histologically. A thin layer of fibrin is made on a microslide by adding a drop or two of fibrinogen to a film of thrombin on the glass. When the fibrin layer has formed, a section of fresh or alcohol-fixed tissue cut on the freezing microtome is applied to its surface and the preparation incubated at 37° C. After 30–60 min. patches of digestion of the fibrin appear in relation to… 
Stability of Fibrin Contiguous to Intima of Veins
TLDR
The rate at which soluble Folin-Ciocalteu reactive material appeared in the incubated media of clots so prepared was significantly higher than that developed in systems containing either everted vein alone or fibrin alone.
Die Lokalisation des Gewebsaktivators der Fibrinolyse bei Dermatosen
  • U. Haustein
  • Medicine
    Archiv für klinische und experimentelle Dermatologie
  • 2004
TLDR
The fibrinolytic activity of parakeratotic psoriatic scales appearing already after 15 to 30 min points out the special pathogenetical position of psoriasis vulgaris with excessively increased epidermopoesis.
The ultrastructure of the lysis of fibrin by endothelium in vitro.
  • B. Warren, S. Khon
  • Biology, Medicine
    British journal of experimental pathology
  • 1974
TLDR
The ultrastructural morphology of this process in vitro was examined and the endothelial cells remained relatively intact throughout the process, though there were indications of injury e.g. vesicular blebs were formed on the luminal surface of the endothelium.
Plasminogen activators: a morphologist's view
  • A. Todd
  • Biology, Medicine
    Journal of clinical pathology. Supplement
  • 1980
TLDR
Many proteases have been described as activators of plasminogen, and these include proteases from leucocytes; from epithelial cells in sites such as cornea and cervix uteri; and from cells in culture, both normal and malignant.
In vitro stimulation of plasminogen activator release from vein walls by adrenaline.
TLDR
The results show that adrenaline has a stimulant effect on tissue fibrinolysis in vitro, and this effect may account for the direct stimulation of fibrin slide activity by adrenaline in vivo.
Thromboplastic and Fibrinolytic Activity of the Human Aorta
TLDR
The simultaneous presence of high thromboplastic activity and little or no fibrinolytic activity found in the intima and the media suggest that fibrin can easily be deposited after tissue injury and that its eventual removal depends upon the humoral fibrinelytic system in the circulating blood.
A simple quantitative assay of tissue plasminogen activator.
TLDR
A simple method for the quantitative assay of tissue plasminogen activator, which gives straight line plots of log weight against log activity of the dilution and the sample activity is calculated from this.
Non-plasminic fibrinolytic enzyme coexisted with plasminogen activator in the peritoneal and alveolar macrophages
In the present study we observed that peritoneal and alveolar macrophages of mice produced non-plasminic fibrinolytic enzyme (NPFE) which was different from plasminogen activator (PA), and the
FIBRINOLYTIC ACTIVITY OF HUMAN BRAIN. A HISTOCHEMICAL STUDY
  • D. Tovi
  • Medicine
    Acta neurologica Scandinavica
  • 1973
TLDR
The fibrinolytic activity of human brain was studied with the “fibrin slide technique” for the localisation of tissue plasminogen activators and found to be low and that of the leptomeninges high.
Histotypic angiogenesis in vitro: Light microscopic, ultrastructural, and radioautographic studies
TLDR
This experimental model, histophysiologic gradient culture, provides a new tool for the study of vascular morphogenesis, angiogenesis dependent growth of tumors, and neoplastic intravasation.
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