Fibrinogen residue γAla341 is necessary for calcium binding and 'A-a' interactions.

Abstract

The fibrinogen γ-module has several important sites relating to fibrinogen function, which include the high affinity calcium binding site, hole 'a' that binds with knob 'A', and the D:D interface. Residue γAla341, which is located in the vicinity of these sites, is altered in three variant fibrinogens: fibrinogen Seoul (γAla341Asp), Tolaga Bay (γAla341Val… (More)
DOI: 10.1160/TH11-10-0731

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