Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death.

@article{IllRaga2015FibrinogenNA,
  title={Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death.},
  author={Gerard Ill-Raga and Ernest Palomer and Eva Ramos-Fern{\'a}ndez and Francesc X Guix and M{\'o}nica Bosch-Morat{\'o} and Biuse Guivernau and Marta Tajes and Vict{\`o}ria Valls-Comamala and Jordi Jim{\'e}nez-Conde and {\'A}ngel Ois and Fernando J. P{\'e}rez-Asensio and Mario Reyes-Navarro and Carolina Caballo and Gabriel Gil-G{\'o}mez and Irene L{\'o}pez-V{\'i}lchez and Ana Mar{\'i}a Gal{\'a}n and Francesc Alameda and Gin{\'e}s Escolar and Carlos M. Opazo and Anna Planas and J Roquer and Miguel A Valverde and Francisco J Mu{\~n}oz},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 3},
  pages={421-8}
}
Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide synthesis to recover blood flow but also induces a free radical burst. Nitric oxide and superoxide anion react to generate peroxynitrite that… CONTINUE READING