Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

@article{Yang2009FibrinogenIR,
  title={Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.},
  author={Hong Yang and Sean Lang and Zhimin Zhai and Ling Li and Walter H. A. Kahr and Pingguo Chen and Jelena Beban Brki{\'c} and Christopher M. Spring and Matthew J. Flick and Jay L. Degen and John J. Freedman and Heyu Ni},
  journal={Blood},
  year={2009},
  volume={114 2},
  pages={
          425-36
        }
}
Platelet P-selectin plays important roles in inflammation and contributes to thrombosis and hemostasis. Although it has been reported that von Willebrand factor (VWF) affects P-selectin expression on endothelial cells, little information is available regarding regulation of platelet P-selectin expression. Here, we first observed that P-selectin expression was significantly decreased on platelets of fibrinogen and VWF double-deficient mice. Subsequently, we identified this was due to fibrinogen… 
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