Fibrinogen does not protect von Willebrand factor against proteolysis by human cathepsin G.

Abstract

The susceptibility of von Willebrand factor /vWF/ to digestion by human neutrophil cathepsin G in highly purified FVIII/vWF concentrate /BHS/ and in cryoprecipitate has been studied. In contrast to human neutrophil elastase, cathepsin G inactivates and degrades vWF not only in BHS but also in cryoprecipitate. Fibrinogen added in excess to purified FVIII/vWF concentrate does not protect vWF against cathepsin G proteolysis. Biological significance of this phenomena are discussed.

Cite this paper

@article{Jelenska1991FibrinogenDN, title={Fibrinogen does not protect von Willebrand factor against proteolysis by human cathepsin G.}, author={Maria Magdalena Jelenska and Magdalena M. Kope{\'c} and I. Sopata and Z Vigh and Inge Scharrer and Karl H. Breddin}, journal={Thrombosis research}, year={1991}, volume={61 4}, pages={433-40} }