Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion.

@article{Redman2001FibrinogenBA,
  title={Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion.},
  author={Colvin M. Redman and Hui Xia},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={936},
  pages={
          480-95
        }
}
Plasma fibrinogen is synthesized primarily in hepatocytes and assembly of the three component chains (A alpha, B beta, and gamma) into its final form as a six-chain dimer (A alpha, B beta, gamma)2 occurs rapidly in the lumen of the endoplasmic reticulum (ER). Assembly takes place in a stepwise manner with single chains interacting with each other to form A alpha-gamma and B beta-gamma complexes. The two-chain complexes then acquire another chain to form half-molecules (A alpha, B beta, gamma)1… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

Similar Papers

Loading similar papers…