Fibrinogen as a key regulator of inflammation in disease

  title={Fibrinogen as a key regulator of inflammation in disease},
  author={D. Davalos and K. Akassoglou},
  journal={Seminars in Immunopathology},
  • D. Davalos, K. Akassoglou
  • Published 2011
  • Medicine
  • Seminars in Immunopathology
  • The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component. Moreover, the identification of novel molecular mechanisms linking coagulation and inflammation has highlighted… CONTINUE READING
    462 Citations
    Platelets and autoimmunity
    • 64
    Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface
    • 41
    • PDF


    Genetic Manipulation of Fibrinogen and Fibrinolysis in Mice
    • 34
    Targeting the coagulation factor fibrinogen for arthritis therapy.
    • 14
    The role of fibrinogen and fibrinolysis in peripheral arterial disease.
    • 50
    Arthritis is linked to local and systemic activation of coagulation and fibrinolysis pathways
    • 151
    Overview of hemostatic factors involved in atherosclerotic cardiovascular disease
    • 175
    Hemostatic factors and inflammatory disease.
    • J. Degen
    • Medicine
    • Thrombosis and haemostasis
    • 1999
    • 52
    • Highly Influential
    Role of protease‐activated receptors in inflammatory responses, innate and adaptive immunity
    • 155
    The missing link between atherosclerosis, inflammation and thrombosis: is it tissue factor?
    • 42
    Fibrinogen signal transduction in the nervous system
    • 84