Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast.

@article{Docherty2011FibrinogenAA,
  title={Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast.},
  author={Neil G Docherty and Catherine Godson},
  journal={Kidney international},
  year={2011},
  volume={80 10},
  pages={1014-6}
}
Fibroblast proliferation is central to the evolution of renal tubulointerstitial fibrosis. Using both in vivo and in vitro approaches, Sörensen et al. describe a role for fibrinogen as a cell-surface-receptor-mediated mitogen for renal fibroblasts. This interaction, likely to be initiated by injury and extravasation and to signal principally via Toll-like… CONTINUE READING