Fibrinogen and fibrin structure and functions

@article{Mosesson2005FibrinogenAF,
  title={Fibrinogen and fibrin structure and functions},
  author={Michael W. Mosesson},
  journal={Journal of Thrombosis and Haemostasis},
  year={2005},
  volume={3}
}
  • M. Mosesson
  • Published 1 August 2005
  • Chemistry, Medicine
  • Journal of Thrombosis and Haemostasis
Summary.  Fibrinogen molecules are comprised of two sets of disulfide‐bridged Aα‐, Bβ‐, and γ‐chains. Each molecule contains two outer D domains connected to a central E domain by a coiled‐coil segment. Fibrin is formed after thrombin cleavage of fibrinopeptide A (FPA) from fibrinogen Aα‐chains, thus initiating fibrin polymerization. Double‐stranded fibrils form through end‐to‐middle domain (D:E) associations, and concomitant lateral fibril associations and branching create a clot network… 
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