Fibrinogen and fibrin structure and functions

  title={Fibrinogen and fibrin structure and functions},
  author={M. Mosesson},
  journal={Journal of Thrombosis and Haemostasis},
  • M. Mosesson
  • Published 2005
  • Medicine
  • Journal of Thrombosis and Haemostasis
  • Summary.  Fibrinogen molecules are comprised of two sets of disulfide‐bridged Aα‐, Bβ‐, and γ‐chains. Each molecule contains two outer D domains connected to a central E domain by a coiled‐coil segment. Fibrin is formed after thrombin cleavage of fibrinopeptide A (FPA) from fibrinogen Aα‐chains, thus initiating fibrin polymerization. Double‐stranded fibrils form through end‐to‐middle domain (D:E) associations, and concomitant lateral fibril associations and branching create a clot network… CONTINUE READING
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