Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'.

  title={Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'.},
  author={Bernard D Keavney and John Danesh and Sarah Parish and Alison Palmer and Sarah V Clark and Linda D. Youngman and Marc D{\'e}l{\'e}pine and Mark Lathrop and Richard Peto and Rory Collins},
  journal={International journal of epidemiology},
  volume={35 4},
BACKGROUND Blood concentrations of fibrinogen have been associated with coronary heart disease risk in epidemiological studies, but it is uncertain whether this association is causal or reflects residual confounding by other risk factors. We investigated the relationship between the single nucleotide polymorphism at position -148 in the beta-fibrinogen gene promoter (beta - 148C/T), blood fibrinogen levels, and risk of myocardial infarction (MI) in sufficiently large numbers of coronary disease… CONTINUE READING
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