Fibrinogen-Related Proteins (FREPs) in Mollusks.

  title={Fibrinogen-Related Proteins (FREPs) in Mollusks.},
  author={Coen M. Adema},
  journal={Results and problems in cell differentiation},
Anti-parasite responses of the snail Biomphalaria glabrata involve antigen-reactive plasma lectins termed fibrinogen-related proteins (FREPs) comprising a C-terminal fibrinogen (FBG) domain and one or two upstream immunoglobulin domains. FREPs are highly polymorphic; they derive from several gene families with multiple loci and alleles that are diversified by exon loss, alternative splicing, and random somatic mutation (gene conversion and point mutations). Individual B. glabrata snails have… CONTINUE READING
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