Fibrinogen Detroit—a Molecular Defect in the N-terminal Disulphide Knot of Human Fibrinogen?

@article{Blombck1968FibrinogenDM,
  title={Fibrinogen Detroit—a Molecular Defect in the N-terminal Disulphide Knot of Human Fibrinogen?},
  author={Margareta Blomb{\"a}ck and Birger Blomb{\"a}ck and Eberhard F. Mammen and Ananda S. Prasad},
  journal={Nature},
  year={1968},
  volume={218},
  pages={134-137}
}
Fibrinogen from a patient with a blood coagulation disorder has an amino-acid substitution (arginine to serine) in the vicinity of the bond split by thrombin during normal blood coagulation.