Fibrinogen Cleveland II. An abnormal fibrinogen with defective release of fibrinopeptide A.

@article{Crum1974FibrinogenCI,
  title={Fibrinogen Cleveland II. An abnormal fibrinogen with defective release of fibrinopeptide A.},
  author={Edward D. Crum and John R. Shainoff and Richard C. Graham and Oscar D. Ratnoff},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={53 5},
  pages={1308-19}
}
An abnormal fibrinogen (fibrinogen Cleveland II) was detected in the plasma of a 23-yr-old white man with a mild bleeding diathesis. The one-stage prothrombin time, thrombin time, and Reptilase time were all prolonged. 16 of 24 tested relatives had the defect, which appeared to be transmitted as an autosomal dominant characteristic. The thrombin time of normal plasma was slightly inhibited by the proband's plasma. The abnormally long thrombin time of fibrinogen Cleveland II was partially… CONTINUE READING