Fibrinogen: structure, function, and surface interactions.

  title={Fibrinogen: structure, function, and surface interactions.},
  author={Cristina Fuss and Julio C. Palmaz and Eugene A. Sprague},
  journal={Journal of vascular and interventional radiology : JVIR},
  volume={12 6},
Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet alpha(IIb)beta(3) [corrected… CONTINUE READING

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