Fibrinogen: biochemistry, epidemiology and determinants.

  title={Fibrinogen: biochemistry, epidemiology and determinants.},
  author={Sridhar Kamath and Gregory Y. H. Lip},
  journal={QJM : monthly journal of the Association of Physicians},
  volume={96 10},
Plasma fibrinogen is an important component of the coagulation cascade, as well as a major determinant of blood viscosity and blood flow. Increasing evidence from epidemiological studies suggests that elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disorders, including ischaemic heart disease (IHD), stroke and other thromboembolism. This increase in plasma fibrinogen levels may promote a prothrombotic or hypercoagulable state, and may in part explain… CONTINUE READING
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