Fibrinogen, blood viscosity, and cerebral ischemia.

@article{Grotta1985FibrinogenBV,
  title={Fibrinogen, blood viscosity, and cerebral ischemia.},
  author={J M La Grotta and Peter T. Ostrow and Eduardo M. Fraifeld and David Elliott. Hartman and H Thorgaard Gary},
  journal={Stroke},
  year={1985},
  volume={16 2},
  pages={
          192-8
        }
}
This study examines the effect of fibrinogen and consequent blood viscosity reduction on cerebral blood flow and cellular injury following severe cerebral ischemia for 30 minutes in 78 Wistar rats. In half of these rats 10 to 15 cc's of blood was removed and replaced with a mixture of 5% albumin and autologous red blood cells maintaining a constant hematocrit but resulting in a 30% decrease in fibrinogen and corresponding reduction in viscosity. Fibrinogen reduction in a slight increase in… CONTINUE READING

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