Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl- phenylalanine

@article{Loike1995FibrinRN,
  title={Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl- phenylalanine},
  author={John D. Loike and Joseph S El Khoury and Long Cao and Charles P Richards and H Rascoff and John T Mandeville and Frederick R Maxfield and Samuel C. Silverstein},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={1763 - 1772}
}
We have examined the capacity of four different chemoattractants/cytokines to promote directed migration of polymorphonuclear leukocytes (PMN) through three-dimensional gels composed of extracellular matrix proteins. About 20% of PMN migrated through fibrin gels and plasma clots in response to a gradient of interleukin 8 (IL-8) or leukotriene B4 (LTB4). In contrast, < 0.3% of PMN migrated through fibrin gels in response to a gradient of tumor necrosis factor alpha (TNF) or formyl-methionyl… CONTINUE READING