Fibrin hydrogels for lentiviral gene delivery in vitro and in vivo.

@article{Kidd2012FibrinHF,
  title={Fibrin hydrogels for lentiviral gene delivery in vitro and in vivo.},
  author={Martha E Kidd and Seungjin Shin and Lonnie D Shea},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={157 1},
  pages={80-5}
}
Gene delivery from hydrogels represents a versatile approach for localized expression of tissue inductive factors that can promote cellular processes that lead to regeneration. Lentiviral gene therapy vectors were entrapped within fibrin hydrogels, either alone or complexed with hydroxylapatite (HA) nanoparticles. The inclusion of HA into the hydrogel led to the formation of small aggregates distributed throughout the hydrogel, with no obvious alteration of the pore structure outside the… CONTINUE READING
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