Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests.

@article{Likhitpanichkul2014FibringenipinAH,
  title={Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests.},
  author={Morakot Likhitpanichkul and Marcel Dreischarf and Svenja Illien-Junger and Benjamin A. Walter and Tadashi Nukaga and Rose G Long and Daisuke Sakai and Andrew C. Hecht and James C Iatridis},
  journal={European cells & materials},
  year={2014},
  volume={28},
  pages={25-37; discussion 37-8}
}
Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are associated with painful conditions and accelerated intervertebral disc (IVD) degeneration. Currently, no effective treatments exist to repair AF damage, restore IVD biomechanics and promote tissue regeneration. An injectable fibrin-genipin adhesive hydrogel (Fib-Gen) was evaluated for its performance repairing large AF defects in a bovine caudal IVD model using ex vivo organ culture and biomechanical… CONTINUE READING
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…