Fibrin generated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis.

@article{SnchezPernaute2003FibrinGI,
  title={Fibrin generated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis.},
  author={Olga S{\'a}nchez-Pernaute and Mar{\'i}a J L{\'o}pez-Armada and Emilio Calvo and Irene Diez-Ortego and Raquel Largo and Jes{\'u}s Egido and G Herrero-Beaumont},
  journal={Rheumatology},
  year={2003},
  volume={42 1},
  pages={19-25}
}
OBJECTIVE Fibrin deposits adhered to the synovial surface are typical of rheumatoid joints. Since fibrin appears to have a role in arthritis perpetuation our aim was to investigate how these deposits are formed and the consequences of their adhesion to the tissue. METHODS The appearance of fibrin aggregates either free in the synovial fluid or attached to the membrane was studied in rabbits with antigen-induced arthritis by histological techniques at different time points from challenge. In… CONTINUE READING

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