Fibrin formation and proteolysis during ancrod treatment. Evidence for des-A-profibrin formation and thrombin independent factor XIII activity.

@article{Dempfle2001FibrinFA,
  title={Fibrin formation and proteolysis during ancrod treatment. Evidence for des-A-profibrin formation and thrombin independent factor XIII activity.},
  author={C. E. Dempfle and Sotiria Argiriou and Sonja Alesci and Klaus Kucher and Herbert Mueller-Peltzer and Klaus Dr Ruebsamen and Dieter L. Heene},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={936},
  pages={
          210-4
        }
}
Ancrod is a purified fraction of venom from the Malayan pit viper Calloselasma rhodostoma, containing a serine protease that cleaves fibrinopeptides A from fibrinogen. We report on a study that involved intravenous and subcutaneous application of ancrod in healthy subjects in which it was shown that ancrod induces the formation of desAA-fibrin complexes that are partially crosslinked by factor XIII proenzyme, and act as cofactor in tPA induced plasminogen activation. The plasmin generated… CONTINUE READING